The former ER actor - currently starring in sci-fi drama Falling Skies - previously revealed that he was a fan of the series as a child.
"[I enjoyed] various incarnations, and [it was] sort of sporadic, although I'm told that I should really get back into it, because it's been a radically reinvented franchise," he told Digital Spy.
"I guess the guy that's now in charge [Steven Moffat] is quite brilliant, so I'm curious to see [what it's like]."
Asked if he would consider a guest role on the BBC series, Wyle said: "Sure, I never turn down work!"
The 41-year-old admitted that science fiction was never his "go-to genre", but added that he enjoys sci-fi "when it's done really well".
"I certainly grew up right there with Star Wars and Star Trek... Close Encounters and films like that," he revealed. "When science fiction is metaphorical storytelling for something else, I tend to enjoy it more."
Falling Skies season two begins Tuesday, July 3 at 9pm on FX.
> Liam Cunningham, David Warner to appear on Doctor Who
Watch an FX trailer for season two of Falling Skies below: