In an interview with the Radio Times, the 29-year-old actor appeared to dismiss rumors that he will leave the BBC sci-fi drama in November 2013.
"We want to make [the anniversary] as big and bold and as brilliant as we can because, we hope, it can be one of the monumental bits of TV history," said Smith. "But I doubt there'll be a regeneration."
He added: "Steven [Moffat] will tease you all right to the end. Because that's what he does to me."
Moffat - head writer and showrunner on Doctor Who - recently told Digital Spy that the anniversary celebrations would be "huge", but added that fans will have plenty to look forward to before 2013.
"We've got an awful lot of stuff to announce before that," he said. "We don't aim to have one event, over a year in the future - we want to make Doctor Who an event every single week. And we're going to pull that off, so... patience!"
Doctor Who will return to BBC One and BBC America on Saturday, September 1.
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Watch the stars of Doctor Who discuss the 50th anniversary with DS below: