The series will be eight issues long, and ties into the 'Fear Itself' event.
Its first issue will also be one of Marvel's 'Point 1' titles, designed as a prelude to the series and a jumping on place for new readers, reports CBR.
The book will be written by Greg Pak and Fred Van Lente with art by Dale Eaglesham.
"You don't have to have read anything to jump on board here," Pak said during Marvel's most recent 'Next Big Thing' panel.
"Old time Alpha Flight fans will have a lot of fun seeing things referenced, but you don't even have to have read an Alpha Flight book before."
Alpha Flight will be branded as traitors when the events of 'Fear Itself' cause a sudden change in the Canadian government.
The title will launch in May.