Artifacts will be written by Ron Marz and illustrated by Stjepan Sejic, spinning out of the limited series of the same name.
It was unveiled during the Top Cow panel at San Diego Comic-Con.
"It's going to deal with the fallout from the Artifacts series, how the world has changed and whether this new world, this new Top Cow Universe, is the way it should be," Marz told Comic Book Resources.
"Is what comes out the other side of Artifacts the way the world is supposed to be? While saying that, we're building it to be pretty standalone. You won't have to have read the 13 issue Artifacts maxiseries to be able to plug into this new series."
Marz further explained: "One of my pet peeves is accessibility. This will say Artifacts on the cover, but I'm going to make sure it's completely accessible for somebody who's literally just picking up their first Top Cow book."
The series will focus on Tom Judge, the bearer of the Rapture who was introduced in the first issue of the current series.
Marz and Sejic had previously teased the project.
The current Artifacts miniseries will be released in September alongside Witchblade #150, which concludes Marz and Sejic's long run on the title.
Artifacts will debut in November.