The image shows Canadian mutant Wolverine attacking Alpha Flight's Guardian.
The team was resurrected during the events of Chaos War.
The new Alpha Flight comic was launched as a limited series tying into 'Fear Itself' before it was upgraded to an ongoing title.
"Alpha Flight is now an ongoing series, but is the team safe as an Avenger heads north?" said Marvel.
Wolverine has a history with the team, who were originally introduced as part of the character's back-story.
The title is co-written by Greg Pak and Fred Van Lente, with art by Dale Eaglesham.
Alpha Flight #5 will be released on October 12. Issue #6 will follow on November 23.