The illustration, by Ivan Reis and Joe Prado, reveals alternate reality versions of Batman, Superman and Wonder Woman.
The cover posted on The Source shows the three heroes fighting an army of Apokoliptian Parademons.
Written by James Robinson and illustrated by Nicola Scott, the series is set on the newly revived parallel Earth and forms part of DC's second wave of New 52 titles.
Robinson has teased the involvement of the Justice Society in the new ongoing title.
Paul Levitz's forthcoming World's Finest series also deals with refugees from Earth 2 struggling to return home.
Reis and Prado are currently collaborating on Aquaman with Geoff Johns.
The Parademons have played a central role in the first arc of Justice League.
Robinson is currently working on The Shade miniseries and will write an upcoming, Vandal Savage-starring arc of DC Universe Presents.
Earth 2 and the five other new titles will debut in May.