Bongo Comics announced the title as part of its quarterly series of 'One Shot Wonders', which will focus on various lesser-known residents of Springfield.
"At signings and conventions, interest in Ralph is always off the charts. I'm happily amazed by the wide swatch of people who claim him as their most beloved Simpsons character," said Bongo creative director Nathan Kane.
"Not only is Ralph Wiggum an everyman, he's everyman's unintentionally hilarious, and unflappable younger brother."
Creators including Sergio Aragonés, Mike Kazaleh, Carol Lay, James Lloyd, Jesse McCann, and Mary Trainor will work on the series of one-shots. Future titles will focus on Milhouse, Homer during his childhood, and Maggie Simpson.
The Simpsons TV show will air its 500th episode this weekend.
> Ultimate Simpsons episode countdown (20-16)