Wrightson will collaborate with 30 Days of Night writer Steve Niles on Frankenstein Alive, Alive!, ICv2 reports.
The book will serve as a sequel to his 1983 title Frankenstein, which is currently in print with Dark Horse Comics.
Niles and Wrightson previously collaborated on 2006's City of Others.
Byrne's project is a superhero series titled Trio, featuring the heroes Rock, Paper and Scissors.
The writer's long-term collaborators, including Joe Sinnott and Tom Palmer, will provide cover illustrations.
IDW published Byrne's first new project in more than a decade when it released Cold War last year.
Frankenstein Alive, Alive! and Trio will debut in May.
> 'Rocketeer Adventures Volume 2' announced by IDW
> IDW Publishing extends comiXology deal, goes day-and-date digital