Brian Michael Bendis has revealed that the 50th anniversary Spider-Man crossover will centre around the 'Ultimate' version of the master of illusion.
"Mysterio is up there with the most dangerous criminals that Spider-Man has come up against," Bendis told USA Today.
"When I was a kid, I found some of his stories to be terrifying. It just got so personal. When he does his thing right, he delves in and gets deep into a psyche that doesn't deserve that kind of punishment."
Marvel Comics' five-issue miniseries sees the mainstream Marvel Universe Peter Parker arrive in the alternate reality where his counterpart is dead - and replaced by Miles Morales - and some of his long-dead loved ones are still alive.
"Now we're in Christmas Carol territory. If done right, this is an emotional and powerful Spider-Man story that we haven't seen before," said Bendis.
"The real meat of the story is [Peter] meeting Aunt May and Gwen [Stacy] and [Mary Jane] and discovering this world and what it means to him. You can't walk away from an interaction like that without being changed, and Miles being witness to it all is the best lesson he can learn."
Bendis is teaming with Ultimate Spider-Man artist Sara Pichelli on Spider-Men, which will debut in June.