The Filipino illustrator, best known for his work on Conan and Batman in the 1970s, died on Wednesday after a short battle with cancer.
His death follows the news that compatriot and fellow comic artist Tony DeZuniga passed away in a hospital following a stroke brought on by a bout of pneumonia.
Filipino cartoonist Gerry Alanguilan has paid tribute to both creators on his blog.
"It's sad to lose one, but it's truly crushing to lose so many in such a short amount of time," he wrote. "But Mang Ernie lived a full life. He had accomplished a lot. There was a point in time that he was one of the hottest artists working comics.
"DC wouldn't give you the honour of drawing so many covers on their mainstream titles if you weren't so well regarded. He deserves to be remembered and recognised as someone who contributed positively to the image of Filipinos and their talents worldwide."
Chan worked on several high-profile titles for DC Comics during his career, including Batman, Claw the Unconquered and Detective Comics. He later jumped ship to Marvel Comics, where he illustrated Kull the Destroyer, Power Man and Iron Fist and more.