The executive said that he felt people were too focused on the superficial changes introduced during the company's September 2011 overhaul, while Watchmen is a more "emotional" issue.
When asked by Digital Spy whether he thought Before Watchmen is bigger than 'The New 52', DiDio responded: "I think so. 'The New 52' was interesting, but most people were so focused on the superficiality of the changes, such as the new costumes and things of that nature.
"The goal for 'The New 52' was to capture everything that made the characters great, and hopefully just contemporise them without changing them."
He added: "Here, this is such an emotional issue for so many people, but I'm hoping everybody walks in with an open mind, because I think they should.
"There's so much love and care put into these series. My hope is that people will see them for what they are, and then from there see if you enjoy them or not."
DC's plans to revive the celebrated 1986 miniseries have been dogged by controversy, with original writer Alan Moore dismissing the project as "completely shameless".
Before Watchmen kicks off with Minutemen #1 on June 6.