The publisher will resurrect the series on Halloween through Vertigo with an 80-page collection of stories from top creators including Jeff Lemire, Geoff Johns, Paul Pope, Gilbert Hernandez and the late Joe Kubert, reports Shock Till You Drop.
"Check out this all-new anthology from some of the biggest talents in the industry," reads the solicitation.
"Stories spotlight a space heist on a ghost ship, a spirit who wants to play synthesizer in a techno band, a ghost-for-hire haunting agency and other dark, twisted tales."
The original Ghosts series ran from 1971 to 1982.
DC has received particular praise for its horror titles, including the critically acclaimed Animal Man, since its relaunch last year.