It reveals a release date of October 23 in North America, with a European launch expected for October 26.
The shooter follows US Tier 1 Operator 'Preacher' returning to his family back home. However, the peace is shattered by explosive detonations in civilian territory, calling him and his squad back into action.
Going beyond the location of Afghanistan from the original game, it sees Tier 1 travel the globe in missions that mirror real world events, from rescuing hostages in the Philippines to eliminating pirates on the Somali Coast.
Campaign missions will feature a degree of choice, elements of co-op and returning characters.
Those who pre-order the game will unlock the Tier 1 Sniper on the day of launch, a weapon said to take 40 hours to otherwise unlock.
Medal of Honor Warfighter will be once again developed by Danger Close using Battlefield 3's Frostbyte 2 engine.
Medal of Honor Warfighter will be available on Xbox 360, PS3 and PC.
> Read our review of Medal of Honor
Watch the launch trailer for Medal of Honor below: