Based on the animated television series of the same name, Transformers Prime will combine "brawler-style" action with "diverse driving sequences".
Players will control autobots from the show such as Optimus Prime, Bumblebee, Arcee, Ratchet and Bulkhead as they fight to stop Megatron and his new secret weapon.
"Hasbro Studios has done a phenomenal job with the Transformers Prime television show," Activision executive vice president David Oxford said.
"We are collaborating closely with the series creators to capture all the adventure, humour and friendships from the show to create an authentic action experience for Transformers fans of all ages to enjoy."
The game is being developed by Now Productions for the Wii and Nintendo 3DS, while a Nintendo DS version is also under way from Altron Corporation.
Watch the first trailer for Transformers Prime below: