The teaser image depicts the iconic silhouette of the Mad Magazine character in what appears to be a redrawn room from the classic Spy Vs Spy game.
The new title is being developed by Robots & Pencils, a studio that has worked on numerous iOS apps and games.
Originally released in 1984 for the Amiga, Commodore 64 and Apple II game, Spy Vs Spy pits two players against each other to retrieve various important materials while trying to thwart their opponent.
The game was inspired by the long-running cartoon strip of the same name, which debuted in Mad #60 in January 1961.
A live-action movie based on the comic strip has also been rumoured, with Ron Howard tipped to direct the project.
> Retro Corner: Spy Vs Spy
Watch footage of Spy Vs Spy on the Amiga below: