The video was released as part of this morning's Nintendo Direct presentation, in which the firm announced the 3DS XL.
The video introduces the game's overworld, characters and battle sequences.
It was previously revealed that the games will take place two years after their predecessors and see players return to the region of Unova. The world has undergone numerous changes since the previous games, and will play host to new characters.
Pokemon Black 2 and White 2 will be the first direct sequels in the series. Nintendo traditionally denotes new additions to the franchise by colour, rather than numerically.
Nintendo officially unveiled the games in February, following a lengthy teaser campaign.
Pokemon Black 2 and White 2 will be released for Nintendo DS in the West this autumn, following the Japanese launch in June.
It will be joined by 3DS apps Pokémon Dream Radar and Pokédex 3D Pro