The video debuted as part of the publisher's showing at San Diego Comic-Con, featuring gameplay footage that emphasises the game's horror elements.
Announced earlier this year, Resident Evil 6 is set 15 years after the Raccoon City incident and features Leon Kennedy, Chris Redfield and newcomer Jake Muller as playable characters for three interwoven stories travelling from the infected American town of Tall Oaks to China.
The game is Capcom's largest ever production, with more than 600 staff involved in its development.
A demo launched last week for Xbox 360 Dragon's Dogma owners.
The demo, which features three different missions, will remain an Xbox 360 exclusive until September, when it releases for the PS3.
Resident Evil 6 will be available from October 2 on Xbox 360 and PlayStation 3. A PC release will follow, but has not yet been dated.
Watch the Resident Evil 6 announcement trailer below: