The company said that it is keen to avoid the pitfalls of the PlayStation Portable, which hosted myriad conversions.
"The issue that happened with PSP is we got overrun with ports," Sony marketing executive John Koller told Gamasutra. "It became very difficult for us to define what made PSP unique.
"The content development became a bit unstructured or decentralised, in that we got a lot of content that was on PlayStation 2 and got thrown over to the handheld."
Koller insisted that Vita titles should be "unique" as portable games are not just played because the player "left the living room".
He advised third-party studios: "Follow what Ubisoft is doing with Assassin's Creed. Follow what Activision is doing with Call of Duty."
The Vita-exclusive Assassin's Creed 3: Liberation and Black Ops: Declassified are released in October and November respectively.
Watch a trailer for Black Ops: Declassified below: