According to Deadline, the comedy sequel - titled American Reunion - will be released on April 6, 2012.
The fourth big-screen instalment will see the original cast members organising a ten-year reunion via Facebook. The movie will show how the characters' lives have changed since 2003's American Wedding.
Jason Biggs, Seann William Scott, Tara Reid, Chris Klein and Alyson Hannigan are among the cast members confirmed to return.
The American Pie series has grossed more than $750 million at the worldwide box office, and spawned several direct-to-DVD movies with Eugene Levy.
Watch the trailer to the original American Pie below: