The Green Lantern star warned that ego-driven celebrities are in danger of creating a "toxic" environment on set and churning out "unsatisfying" pieces of work.
"It's toxic on a set when you're competitive with other actors," he explained to Virgin Media.
"Whenever I've worked with another actor who's been competitive, usually nine times out of ten it's backfired on them - they've had a really unsatisfying experience. A film is so collaborative. It's the sum of its parts."
Watch Ryan Reynolds talk to Digital Spy below:
Reynolds insisted that there were no such issues when he starred alongside Sandra Bullock in 2009 rom-com The Proposal, and added that he would be open to working with her again.
"My producing partner is incredibly close with Sandra - we all met up about ten years ago and we've been good friends since. I never thought we'd do a film together but it worked out," he said.
"Movies like that are so contingent on that chemistry - it's a rare thing if you get it, so if I was going to do another romantic comedy I would hope it would be with Ms Bullock."
Reynolds recently confessed that he considers work to be one of his few hobbies.
Watch the Green Lantern trailer below: