The Jane Eyre star said she loved learning more about the moviemaking process on the set of Tim Burton's picture, but confessed that she struggled to deal with the green screen technology involved.
"It was the best education - seeing how Tim worked, learning from him and absorbing the whole environment," she told Total Film.
"The green screen was very challenging as you can't judge what's happening. You rely on people telling you what kind of atmosphere you are in. It's the most difficult kind of acting. You have to trust the director because you can definitely feel lost."
Wasikowska previously described Alice In Wonderland as an "acting school", saying it "showed that, as an actor, you have to be prepared to do things that you could completely mess up, or that people may not like".
On the CGI work, she added: "It really meant a leap of faith, and having to trust Tim. But it's hard, because you're really filming in a void."
Watch the trailer for Alice In Wonderland below:
> Wasikowska: 'I've been haunted by Alice'
> Mia Wasikowska Jane Eyre interview: "I goofed around with Michael Fassbender"