The Rock of Ages star will take on the role of Adam in the drama, to be directed by I, Robot's Alex Proyas, according to Deadline.
Paradise Lost centres on the battle between archangel Michael and angel Lucifer, who falls from God's grace. Adam and Eve's banishment from the garden after giving into temptation partly brings about the war between heaven and earth.
Boneta will be joining a cast which so far includes Casey Affleck, Djimon Hounsou and Dominic Purcell, who has been cast as an agent of Lucifer.
Bradley Cooper and Benjamin Walker will be battling it out in the roles of Lucifer and Michael, respectively.
In September, Mexican singer-turned-actor Boneta joined the cast of MTV's new drama Underemployed.
He has previously been seen in Beverly Hills, 90210 and Pretty Little Liars.