Rogen was host of the event, which honors independent filmmaking in Hollywood. Although he recently said he has no plans to return to stand-up comedy, Rogen opened the show with a routine that was greeted with raucous laughter from audience members including Zoe Saldana, Joseph Gordon Levitt and Harvey Weinstein.
As The Huffington Post reports, the 50/50 actor poked fun at celebrities including Brett Ratner, Mel Gibson and Chris Brown during his monologue.
"The best thing to come of awards season," Rogen began, "is we learned what a horrible bigot Brett Ratner is." This was in reference to Ratner's homophobic slur which forced him and original Oscars host Eddie Murphy to resign as producer of the ceremony.
Rogen went on to take a jab at Chris Brown's history of assault, saying that Ratner was better suited to the Grammy Awards because "you can literally beat the s**t out of a nominee and be asked to perform twice".
Rogen then made a final joke about the Ryan Gosling movie Drive, which stars Albert Brooks and Ron Pearlman as gangsters, quipping: "Drive made Jews so scary I thought Mel Gibson directed it."
The Artist earned the biggest awards at the ceremony, including 'Best Feature' and 'Best Actor'. The film has been sweeping awards both in Europe and the US, and tonight will compete at the Academy Awards for 'Best Picture'.
Watch the trailer for The Artist below: