Pitt said he has learned over his long career that all Hollywood studios really care about is turning the largest profit possible on their films.
"It's the age old battle of art versus commerce. And it will always be. I don't really wrestle with the relationship of the two," the Oscar nominee said, reports Flicks and Bits. "They're not meant to get along, yet they're symbiotic - they need each other."
He continued: "It's a symbiotic relationship and it's cantankerous and it will always be that. There's something noble about making something that says something and uncovers something, and being able to do it within that system where it has to be profitable, or the thing doesn't get made. I find it a really interesting relationship, I don't argue with it though."
Pitt is currently promoting the gangster film Killing Them Softly, which he has denied is an attack on Barack Obama's role in the 2008 financial collapse.
Killing Them Softly is released in the US on September 21.
He will also appear with Michael Fassbender and Javier Bardem in Ridley Scott's The Counselor.
Watch a preview clip from Killing Them Softly below: