Rodrigo Cortés's follow-up to 2010's Buried stars Murphy and Sigourney Weaver as physicists who investigate supernatural hoaxes, but begin to question their sceptical view of their field after an encounter with a psychic played by De Niro.
De Niro, Murphy, Weaver and Elizabeth Olsen are all shown in character on the posters, which were first revealed by MTV.
The first poster for the film was debuted exclusively through Digital Spy earlier this month.
Red Lights opens on June 15 in the UK, and July 13 in the US.
Watch Digital Spy's recent interview with Elizabeth Olsen below: