A number of Stone's co-stars and friends prepared a video saying what they love about the Amazing Spider-Man star, but it quickly degenerated into everything that is awful about her.
"I saw her kick a blind kid once," Jim Carrey joked.
However, when Stone took the stage, she was surprisingly touched.
"Thank you," she told the crowd before wiping away some tears. "I'm a crier.
"I hope that you'll find your trailblazers... that you'll continue to harness your own originality," she continued. "What sets you apart... is what makes you great. I am deeply touched and grateful for this."
The 2012 MTV Movie Awards aired live from the Gibson Amphitheatre in Universal City, California in the US, and will be broadcast on Monday, June 4 at 9pm in the UK.
> MTV Movie Awards 2012: Live blog
> Jim Carrey: 'Emma Stone video was funny but true'
> MTV Movie Awards 2012: The winners in full
Watch Emma Stone in a trailer for The Amazing Spider-Man below: