The 69-year-old star has acted for 40 years, and is best known for films such as The Long Good Friday, Who Framed Roger Rabbit and Nixon.
A statement read: "Bob Hoskins wishes to announce that he will be retiring from acting, following his diagnosis of Parkinson's disease last autumn.
"He wishes to thank all the great and brilliant people he has worked with over the years, and all of his fans who have supported him during a wonderful career.
"Bob is now looking forward to his retirement with his family, and would greatly appreciate that his privacy be respected at this time."
Hoskins's most recent movie performance came as the dwarf Muir in Snow White and the Huntsman.
Bob Hoskins - a career in pictures: photo gallery
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