His track 'Love The Way You Lie' - a collaboration with Rihanna - rockets from five to number one this week to become his seventh Aussie chart-topper.
Enrique Iglesias and Pitbull hold steady at two with 'I Like It', while Perry slips to three with 'California Gurls'.
Meanwhile, Gym Class Heroes frontman Travie McCoy climbs from six to five with 'Billionaire', his debut solo single.
The only new track in the top ten comes from Adam Lambert, who jumps from 12 to eight with 'If I Had You'.
Mark Ronson & The Business Intl score the highest new entry of the week, landing at 24 with 'Bang Bang Bang'.
The top ten singles in full (click where possible for our reviews):
1. (5) Eminem ft. Rihanna: 'Love The Way You Lie'
2. (2) Enrique Iglesias ft. Pitbull: 'I Like It'
3. (1) Katy Perry ft. Snoop Dogg: 'California Gurls'
4. (3) B.o.B. ft. Hayley Williams: 'Airplanes'
5. (6) Travie McCoy ft. Bruno Mars: 'Billionaire'
6. (4) Uncle Kracker: 'Smile'
7. (8) David Guetta & Chris Willis ft. Fergie & LMFAO: 'Gettin' Over You'
8. (12) Adam Lambert: 'If I Had You'
9. (7) Usher ft. will.i.am: 'OMG'
10. (10) Eminem: 'Not Afraid'