The pair will also include The Muppets in their stage show, as well as a number of other unannounced stars, says People.
Paltrow and Cee Lo collaborated for a performance on Saturday Night Live last month. They also recently recorded a new version of the singer's 'F**k You!'.
It is not yet known what track the two will perform at the awards ceremony.
The 53rd annual Grammy Awards take place at the Staples Centre, Los Angeles on Sunday, February 13.