The rapper made reference to the British singer and Florence + the Machine during his headline concert at London's O2 Arena.
Speaking about his adoration for the artists, Drake told Capital FM: "Florence is like one of my dear, dear friends, so supportive of me, and did a great cover of 'Take Care'.
"Her album is so phenomenal and I actually sample Florence on my album - nobody really detected that but there's a little Florence sample in 'We'll Be Fine'."
In reference to the joke that he made during his performance about Adele's ever-continuing chart success, he added: "Well I'm a big Adele fan so I had to make a little Adele joke at the show because she's so successful - obviously in London - but where I'm from also.
"I think she's the biggest artist in the world right now so she deserves it."
Drake recently confessed that he turned to prescription pain medication and marijuana in the past to deal with his newfound fame.
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Watch the music video for Drake and Rihanna's 'Take Care' below: