The socialite will appear at the 30,000-capacity Pop Music Festival in Sao Paulo, Brazil.
Her set will follow performances from Kelly Clarkson and Jennifer Lopez on June 23.
"I cannot wait to DJ for the first time in front of thousands of people," Hilton told Billboard.
"I have been a part of the music scene and club scene since I was 15. It's something I have been passionate about and have come to respect very much. I am very excited to share all of my hard work with the world."
Hilton has joined her dance music producer boyfriend Afrojack to a number of events and festivals over the past few months, and has appeared beside him at some of his performances.
Sources suggest that her set will include "custom-made remixes of the best tracks".
Hilton added: "It is going to be the first of many!"
The reality TV star will also debut her new single 'After Midnight' next month. Afrojack has produced the single, which also features LMFAO.
Watch the video for Paris Hilton's 'Stars Are Blind' below: