The record, which was released in 2004, hit the milestone this week, making it only the 19th album to achieve the feat since Nielsen SoundScan started tracking data in 1991.
Confessions sold 2,000 copies in the week ending July 1, Billboard reports.
The last album to sell 10 million copies was Eminem's The Eminem Show, which was released back in 2002 and hit the huge sales threshold in October 2011.
The highest-selling album since SoundScan started recording the data is Metallica's Metallica, having sold 15.8 million units. Shania Twain's Come On Over is in second place with 15.5 million, followed by Alanis Morissette's Jagged Little Pill with 14.8 million.
Confessions, which debuted at number one on the Billboard 200 chart, remains one of only 17 albums to sell over 1 million units in a single week.
The record included the number one singles 'Yeah!', 'Burn' and 'Confessions Part II'.
Usher recently joked that people should stop buying Adele's 21 because it was close to breaking his sales record for Confessions.
Watch the video for Usher's 'Confessions Part II' below: