The actress, who has two children from her ex-husband Ryan Phillippe, said that her kids are the "best part" of her day.
Witherspoon, who is dating Hollywood agent Jim Toth, told Glamour: "I would love to have more kids. Kids are the best part of my day. I don't wake up to make movies. I wake up to hang out with my family."
The 34-year-old also insisted that she doesn't find it easier dating someone who isn't famous but described her partner Toth as "wonderful."
She explained: "I have a little perspective on this. I wouldn't say it's easier. Every relationship has its own dynamic. And I don't want to disparage any of the other relationships that I've had that were meaningful and wonderful.
"But what I'm finding out is that it's very comfortable to be with somebody who understands my career, but doesn't do what I do. He's a great guy. He's wonderful."