The 39-year-old radio and television personality, who was filming for Australia's Got Talent on Saturday night, had to be taken to St Vincent's Hospital in Sydney due to high blood pressure.
A source told The Daily Telegraph: "He was checked out by the medics on set, who quickly realised his blood pressure was through the roof."
Sandilands's representative added: "Kyle got through most of the day's taping but was feeling unwell and couldn't finish the day. He's home and resting up."
The star was told in 2008 that he should quit smoking and drinking too much caffeine or risk dying young.