Davis cited irreconcilable differences as the cause of the split in her divorce papers, which were filed in LA this month, reports TMZ.
They married in December 2006 at London's St Paul's Cathedral in a ceremony attended by Office co-creator Stephen Merchant, as well as Davis's co-stars Martin Freeman and Mackenzie Crook.
Davis and Yeoman were rumoured to have split in 2008, but they reportedly reconciled later in the year.
The couple have no children together.
Davis famously played kind secretary Dawn Tinsley in the original Office, providing the basis for Jenna Fischer's Pam Halpert on the US version.
Yeoman's series The Mentalist airs Thursdays at 10/9c on CBS.
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Watch amateur footage of Lucy Davis and Owain Yeoman's wedding below: