The Horrible Bosses actress, who split from Pitt in 2005 after a five-year marriage, said that the public's fascination with stories about an apparent "feud" between herself and the Moneyball star and Jolie is an ongoing source of revenue for the tabloids that continue to report on it.
"The triangle with my ex-husband - and that there's a feud there - it's constant," Aniston explained in an interview with InStyle.
"It's a story headline that won't go away, but it's a money thing. [It's] a story that has nothing to do with reality."
The 42-year-old, who is currently dating Justin Theroux, also spoke out on the experience of getting older in Hollywood, adding: "You know what makes me feel old? When I see girls who are 20-something, or the new crop of actresses, and think, 'Aren't we kind of the same age?'
"You lose perspective. Or being offered the part of a woman with a 17-year-old child. It's like, 'I'm not old enough to have a 17-year-old!' And then you realise, well, yeah, you are."
Pitt previously appeared to claim that he wasn't living an "interesting" life while married to Aniston, though he later clarified the remarks, saying that he still considers her to be a good friend.
> Jennifer Aniston, Brad Pitt have near-miss reunion
Watch the trailer for Jennifer Aniston's Wanderlust below: