The former ER star was taking part in a protest against Congress's proposed cutting of Medicaid, the US health programme for people and families with low incomes and resources.
Wyle was arrested along with more than 100 members of the grassroots disability rights organisation ADAPT, according to The Huffington Post.
ADAPT claims that cuts to Medicaid spending would mean the disabled and elderly would be forced to leave their houses and enter nursing homes in order to get the support they need.
Wyle currently stars in alien invasion series Falling Skies.
> Read Digital Spy's Falling Skies interview with Noah Wyle
> Noah Wyle had misgivings about 'Falling Skies'
Watch a promo for the new season of Falling Skies below: