The 'Young, Wild & Free' rapper was first caught by authorities in Nashville, Tennessee on April 21 when patrons at a local Holiday Inn motel complained of smelling the drug coming from Khalifa's room.
TMZ reports that Khalifa was cited for a second time on May 1 in Winston-Salem, North Carolina, when he was found to be in possession of 11.39 grams of pot on his tour bus before performing a concert.
He and "other members of his band and staff" were given a ticket and must appear in court to answer the charges on July 27.
In November 2010, Khalifa was arrested for marijuana possession in Greenville, North Carolina, when police recovered over 60 grams on his tour bus.
He was later cleared of felony charges but was forced to plead guilty to a misdemeanour as well as pay a $1,000 fine.
Watch Wiz Khalifa's video for 'Black & Yellow' below: