The rapper was hospitalised last month after his SUV collided with a Mack Truck on the Long Island Expressway.
50 Cent has now spoken about the accident with MTV News, revealing that the driver of the other vehicle "lost control" because "his load shifted".
"He tried to brake, his load shifted and he lost control and he ran into the back of [my] truck," he said. "It did more damage to the Mack Truck than it did to my truck, because I've got a level six - it's a bulletproof vehicle. It's the same standard as what they're moving Obama around in."
50 Cent also denied rumors that his crash was a publicity stunt ahead of the release of his new album Five (Murder by Numbers).
"Trust me, I have enough money to not hit myself with a Mack Truck to try to get a few dollars," he said. "What's the thought process on this? It makes no sense to me."
50 Cent was also hospitalised in May after suffering from a stomach bug.