The 'Slow Motion' rapper was apparently in Miami for a concert reunion with former Hot Boys bandmate Lil Wayne at the LIV nightclub.
Juvenile appeared on-stage with Lil Wayne, but hours later is said to have become involved in a fight inside the venue.
Police were called to the scene and arrested the musician when the fight spread to outside the LIV nightclub, according to TMZ.
LIV security guards apparently claimed that Juvenile was "creating a threat to life and property as well as the overall safety of the patrons inside" in a statement to police.
Juvenile has since been released from custody and insisted that Lil Wayne had no involvement with the fight.
He is best known for a string of hits in the late 1990s and early 2000s, including 'Ha' and 'Back That Azz Up'.
Watch Juvenile's 'Slow Motion' music video below: