The actress, best known for her soap role as Alicia Gallagher, gave birth to a baby boy in the early hours of this morning (August 1).
Anderson and husband James Shepherd have not yet named the child, who weighed in at 6lb 5oz, Hello reports.
The Emmerdale press team tweeted: "Lovely baby news! @AndersonNatalie has given birth to a gorgeous boy! Congratulations Natalie and James."
Anderson announced her pregnancy back in March, before confirming the sex of her baby a few days later.
Emmerdale viewers recently saw Alicia receive a prison sentence for attacking Val Pollard, taking her off screen while Anderson is on maternity leave.
The feisty barmaid is expected to return to the village by the end of the year.