The pair's relationship hits the rocks in tonight's (May 14) double bill as Eileen kicks Paul out of her home after he blames her for the death of his wife Lesley.
Alzheimer's sufferer Lesley lost her life last week as she had a tragic accident in the kitchen after Eileen left her alone for a short time.
Hirst told itv.com of the ongoing storyline: "Eileen does decide that she can't go on with Paul - that he's a reminder of what's happened, and they need to distance themselves from each other because it's too painful."
He continued: "Is this the end of Paul and Eileen for good? I couldn't possibly comment! At the moment, it looks very much that way.
"But I know that when they go away and reflect, they will miss each other deeply. They've been scarred by this massive event, but they've also been enriched by it, I think. I would hope that aspect of the relationship is able to flourish."
Sue Cleaver, who plays Eileen, was spotted filming Lesley's funeral scenes with Hirst a month ago.