The actress, who left her role of Sarah-Louise Platt in 2007 after eight years, revealed that she would rather return herself to the ITV soap.
"Sometimes I think they could bring Sarah-Lou back but with a different face, played by someone else," she told The Mirror. "That happens - but it would be awful!"
Sarah's half-brother Nick Tilsley, who was played by Adam Rickitt while O'Brien was on the Street, was replaced by Ben Price in December 2009.
Since leaving Weatherfield, O'Brien has landed parts in hit BBC shows Waterloo Road, Accused and - most recently - Call the Midwife.
Meanwhile, the 29-year-old revealed that bosses had informally asked whether she would make a comeback during her time on Waterloo Road last year.
"They did ask me back once, but I'd just signed to do Waterloo Road so there was no way I could," she added.
Speaking about her original departure five years ago, the 29-year-old said: "I had the best eight years ever on Corrie, I loved it. But I had been there since I left high school at 16 and felt I had to go.
"It was all I'd known and I had to get out and experience the big wide world. But now that I'm older, yes, I would love the opportunity to go back one day."
Tina O'Brien has a daughter Scarlett with former co-star and on-screen lover Ryan Thomas (Jason Grimshaw), but split with him off-screen in 2009.