Goodyear, who is currently in the Celebrity Big Brother house, has long been linked with a comeback.
Speaking to the latest OK! magazine, the actress stated: "Would I go back? No."
The 70-year-old explained that the soap, which films nearly two hours of material every week, would be too physically gruelling.
"The schedule now is way above and beyond," Goodyear hypothesised. "When I began it was two episodes a week. It's become more and more."
Goodyear further claimed that, while she respects the current cast's level of commitment, her performance would suffer with such high-turnaround scenes.
"I've tremendous admiration for them being able to do it, but I'm a perfectionist in my work," she added. "I need rehearsals, tech-runs, make-up and costume."
The Weatherfield legend, who was last seen on the cobbles in 2002, was previously rumoured to be making a guest appearance for the funeral of Betty Williams last year.
The star briefly reprised her Bet Lynch role in March for blighted Corrie musical Street of Dreams.