The portal allows subscribers to download security software from McAfee, Microsoft, Symantec, Trend Micro or Sophos, and use it for free for up to six months.
"Truly effective security requires co-operation and we are excited about this partnership with many of the leaders in the security community to better help us defend against existing threats, anticipate new ones and arm people with the tools they need to protect themselves," read a statement from Facebook.
Under the terms of the promotion, users are limited to products from one of the five vendors. The anti-virus partners will also update a new area of the site called the Facebook Security Blog, which will contain advice for tackling rogue software.
Mark Zuckerberg's firm identified user security as a top priority ahead of the company's floatation on the stock market. As a precaution, the social network has expanded its web address blacklist to incorporate a host of other malicious sites identified by the security companies.
"This means that whenever you click a link on our site, you benefit not just from Facebook's existing protections, but the ongoing vigilance of the world's leading corporations involved in computer security," the firm explained.
"At the moment, less than 4% of content shared is spam (compared to nearly 90% of email) and we are looking forward to making even more progress in the future."
Facebook earlier this week announced that it has surpassed the milestone of 900m members worldwide, and values itself at $77 billion (£47.6bn).