Deadline says that O'Malley, who plays Kurt's father Burt in Glee, has landed the lead role in the project.
The show focuses on O'Malley's character Dave, a patriarch who insists on taking his family on holiday so that they can spend some quality time together.
Dave is described as a "passionate" and "overly enthusiastic" former jock.
O'Malley reportedly had the choice of working on Family Album or NBC's project Grimm but decided to join the former. As well as starring in Glee, he has had roles in shows including Parenthood and My Name Is Earl, as well as appearing in the movie Eat Pray Love.
Earlier this week, it emerged that Rob Huebel has also signed up for a role in Family Album.