The talkshow host admitted that she was consumed with "rage" for a long time, but added that receiving estrogen treatments has helped her to become happier.
"You know, I think I had a lot more rage than I was aware of," she told O, The Oprah Magazine. "I've gotten back access to my other feelings. I'm not cut off from my emotions anymore… The rage has gone away… There's been a healing.
"I had, like, zero estrogen. Since I got some, I've been able to function more normally. I've stopped being so angry."
O'Donnell recently said that she'd like Russell Brand to be the first guest on her upcoming OWN chatshow.
The comic also claimed that she's a good fit for Oprah Winfrey's OWN channel because people can relate to her.
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Watch Rosie O'Donnell's controversial 1999 interview with Tom Selleck below: