The Seinfeld actress plays Selina Meyer in the HBO show, a senator from Maryland-turned-vice president.
"This is in no way a parody of [Sarah Palin] or any other female politician," Louis-Dreyfus told Capitol File.
"You will never know what party she's in. There's talk of the opposition and that party and this party, but it is never identified. So this is not a partisan politics show in any way.
"What it is, though, is a show about political behaviour. And that is where the comedy comes from. The right thing happens for the wrong reason, or the wrong thing happens for the right reason."
She added: "It is for anybody who likes a good joke. We poke fun at it all, all politicians, and the way Washington is run."
"Let me just put it this way: We think it's really f**king funny. We can't sit through scenes sometimes for quite a while because it's making us laugh so hard. It's going to be unbelievably raunchy and funny."
Veep has been penned by Armando Iannucci (The Thick of It, In The Loop) and directed by Chris Morris (The Day Today, Four Lions). It also stars Anna Chlumsky and Tony Hale.