The project, directed by Night at the Museum's Shawn Levy, will star Moore as Annie, a newlywed who gets the chance to run a hip new restaurant with her husband.
However, when she returns to her hometown, Annie comes under siege from her demanding family.
Former Roswell star Delfino will play Annie's divorced sister who is still living with her parents, according to Deadline.
The actress recently appeared in two episodes of TNT's axed comedy Men of a Certain Age and also starred in ABC Family sitcom State of Georgia.
The Office's Bob Fisher and Kitchen Confidential's Stacy Traub have scripted the Moore / Delfino pilot, which will be co-produced by 20th Century Fox TV.
Other comedy pilots at ABC this season include identity-swap sitcom Prairie Dogs with Kal Penn and Cary Elwes, How to Live with Your Parents for the Rest of Your Life with Scrubs star Sarah Chalke and Weeds' Elizabeth Perkins, and The Smart One featuring Malin Akerman, Portia de Rossi and David Arquette.
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