Fallon will be interviewing Obama as part of a special show from the campus of The University of North Carolina at Chapel Hill on Tuesday, April 24.
The interview will mark Obama's first-ever appearance on Fallon's Late Night.
Dave Matthews will also be on hand as the show's special musical guest alongside The Roots.
The US President's interview comes as part of his campaign to win re-election in November.
Late Night with Jimmy Fallon airs weeknights at 12:35am EST on NBC.
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